Xing M, Liu X, Liu R, Pai S , Zeiger M, Bishop J. TERT Promoter mutation cooperates with BRAF mutation to promote thyroid cancer recurrence. It is associated with increased recurrence and mortality. Two mutations (C228T and C250T) in the promoter region of the telomerase reverse transcriptase (TERT) have recently been described in different types of cancer including follicular cell-derived thyroid cancer (TC). Sun H, El-Naggar AK, Xing M. Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Mutations in the TERT promoter, ALK rearrangement, and the BRAF V600E mutation are associated with aggressive clinicopathologic features in thyroid cancers. Article PubMed PubMed Central Google Scholar 13. It is highly prevalent in old age, large tumor, aggressive histology, advanced stages, and distant metastasis. 20(4), 603–610 (2013). Article PubMed Google Scholar 12. TERT promoter mutation (17%) … BRAF mutation was the most prevalent (89%) in aggressive variants of PTC compared to that in other thyroid cancers. Our aim was to define the ultrasonographic features of telomerase reverse transcriptase promoter-mutated papillary thyroid cancer and to evaluate their predictive performances. TERT promoter mutations are emerging prognostic biomarkers in multiple cancers and are found in highly aggressive thyroid cancer. In this paper, we reviewed the rates of these mutations in different types and subtypes of TC, their association with a number of clinical and … Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Thyroid. Liu X, Bishop J, Shan Y, Pai S, Liu D, Murugan AK, et al. Endocr Relat Cancer . 10. Liu X, Bishop J, Shan Y, et al. 2. PubMed Abstract | CrossRef Full Text | Google Scholar Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr Relat Cancer 2013;20:603-10. doi: 10.1530/ERC-13-0210. MA Blasco: Telomeres and human disease: Ageing, cancer and beyond Nat Rev Genet 6: 611 – 622, 2005 Crossref, Medline, Google Scholar: 16. Highly prevalent TERT promoter mutations in aggressive thyroid cancers. PubMed Google Scholar Crossref Liu X, Bishop J, Shan Y, Pai S, Liu D, Murugan AK, et al. However, little is known about the impact of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of BRAF mutations.. … Mutations 1 295 228 C > T and 1 295 250 C > T (termed C228T and C250T respectively), corresponding to -124 C > T and -146 C > T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene, have recently been reported in human cancers, but not in thyroid cancers yet. Relat. 2013;20(4):603-610. Concomitant BRAF and TERT promoter mutations worsen the survival rate. Cancer. Landa, I. et al. Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr Relat Cancer (2013) 20:603–10. PURPOSE: Telomerase reverse transcriptase promoter mutations are found in highly aggressive thyroid malignancies. RAS mutation was identified in one patient (3%), which was less frequent than in others. 2013;20:603–10. Endocr Relat Cancer. Endocr. Background. doi: 10.1530/ERC-13-0210. Our aim is to investigate the prognostic value of these mutations for the outcome of thyroid cancer-related mortality in a large cohort of thyroid cancer patients. X Liu, J Bishop, Y Shan, etal: Highly prevalent TERT promoter mutations in aggressive thyroid cancers Endocr Relat Cancer 20: 603 – 610, 2013 Crossref, Medline, Google Scholar: 15. 3.1 Detection of canonical and novel TERT promoter mutations in thyroid cancer To search for novel TERT mutations, 301 thyroid tumor samples representing common types of thyroid cancers were subjected to Sanger sequencing analysis of the extended TERT promoter region (424 bp upstream and 64 bp downstream of the translation start site). It was found in 10 to 20% of differentiated thyroid carcinoma and 40% of dedifferentiated thyroid carcinoma.
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